Design and synthesis of dysidiolide analogs from vitamin D3: novel class of Cdc25A inhibitors

Rumiko Shimazawa; Toshiyuki Suzuki; Kosuke Dodo; Ryuichi Shirai

doi:10.1016/j.bmcl.2004.03.100

Design and synthesis of dysidiolide analogs from vitamin D3: novel class of Cdc25A inhibitors

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3291-4. doi: 10.1016/j.bmcl.2004.03.100.

Authors

Rumiko Shimazawa¹, Toshiyuki Suzuki, Kosuke Dodo, Ryuichi Shirai

Affiliation

¹ Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

PMID: 15149692
DOI: 10.1016/j.bmcl.2004.03.100

Abstract

Potent dysidiolide analogs were synthesized by structural hybridization of dysidiolide and vitamin D(3). These analogs exhibited strong inhibitory activity toward dual-specificity phosphatase Cdc25A (IC(50)=0.44-0.89 microM).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

4-Butyrolactone / analogs & derivatives*
4-Butyrolactone / chemical synthesis*
4-Butyrolactone / pharmacology
Cholecalciferol / analogs & derivatives*
Cholecalciferol / pharmacology
Drug Design*
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology
Humans
cdc25 Phosphatases / antagonists & inhibitors*
cdc25 Phosphatases / metabolism

Substances

Enzyme Inhibitors
Cholecalciferol
CDC25A protein, human
cdc25 Phosphatases
dysidiolide
4-Butyrolactone